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Gastrointestinal side effects comparison Retatrutide has a notably higher GI side effect burden at maximum doses

Poor sleep increases cortisol levels, promotes fat storage, reduces insulin sensitivity, and intensifies hunger signals

Metformin is an oral hypoglycemic drug used for the management of T2D and pre-diabetes in individuals with obesity

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Furthermore, Gclc -deficient FoB have a block in the mitochondrial electron transport chain (ETC) due to diminished complex I and II activity and thereby accumulate the tricarboxylic acid cycle metabolite succinate